Subject: HOW TO END THE WAITING LIST FOR ORGAN TRANSPLANTS. Article 
v.94/11/06 by Trygve Bauge. Copyright 1994 
Newsgroups: alt.dear.whitehouse,alt.politics.clinton,
alt.politics.usa.republican,alt.current-events.usa,alt.rush-limba
ugh,alt.society.civil-liberties,alt.visa.us,alt.hemp,alt.politics
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Summary: This is an article from Active Life Extension, the life
extension manual, for more try http://www.powertech.no/~trygveb/
Keywords: Individual life extension, entrepreneurial liberty,
(including freedom-of-contract, -travel and -trade) and private
property, promoted and defended.
Reply-To: trygveb@powertech.no,president@whitehouse.gov
Followup-To: alt.dear.whitehouse,sci.life-extension
--text follows this line--

In his book Active Life Extension, TrygveB@Powertech.No says 
the following, (of which any part, sentence or combination of such
created by him, is also) copyrighted by him in 1994 or preceeding
years:

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THE ARTICLE FOLLOWS:
--------------------

HOW TO END THE WAITING LIST FOR ORGAN TRANSPLANTS. HOW CRYONICS CAN
BE USED TO DO AWAY WITH HAVING TO WAIT FOR ORGAN TRANSPLANTS.

(Copyrighted in 1994 & earlier by Trygve B. Bauge. Distributed by
Active Life Extension. All rights reserved. Copyfee charged. 
Each oneliner, sentence, paragraph, article & file is assumed
created by me until proven otherwise & is copyrighted separately.
Contact the author TrygveB@Powertech.No for permission to 
reproduce or quote this article or any part of it.)

By learning how to make organs survive freezing
we could not just remove the waiting lists for organ transplants
but also use the same knowledge
to make humans survive freezing.

Many people are waiting and waiting
for organ transplants,
living miserably or even dying 
without getting the organs that could have 
made such a difference in their lives.

Organs are hard to keep viable,
and though it might still be viable when it is found
there might not be enough time left to remove it,
transfer it, track down a match and use it,
before it is no longer viable.

If we could find a way to get organs to
survive freezing and thawing,
then we could cut down the biological damage
that takes place between retrival and implantation
by freezing organs in the field,
and thawing them out just before implantation.

This would both lengthen the shelf life of organs 
make it viable to retrieve organs more hours after death,
increase the number of organs that aren't too old to be retrieved
and make many more organs retrievable and worth retrieving
when we get to them in the first place.

Then we could routinely harvest and store 
many more organs, and thus do away with the waiting lists
for organ transplants.

If I was on such a waiting list, I would certainly support more
research into finding a way to make organs survive freezing.

If we studied plants and animals that naturally survive freezing,
found the gens involved and changed the human gen pool so that
future generations of humans could survive being frozen,
then their organs would survive freezing too.

Or maybe we could at least identify and add to the human genome
such genes that would enable us to survive dehydration or much
higher salt concentrations in our cells and body fluids?

The alternative is to induce in the cells through outside meassures
the ability to survive both freezing and fluctuations in the
concentration of tissue salts and to induce this in enough of the
organ's cells so that the organ would stay viable.

We already know how to make cells survive freezing and thawing,
and with enough research we should be able to find ways
to reliably reach and prepare all the cells for the freezing
and thawing.

How can we do to each cell in an organ what we are already doing
to individual cells? 

The problem of continuously reaching all the cells in an organ, the
same way we can continuously reach an individual cell, is a
question of keeping up circulation and fluid pressure or preventing
coagulation while cooling the cell, and this could be done by
lowering the coagulation and freezing points for body fluids.

If we can can't keep fluids running in the blood vessels
through out the freezing and thawing
maybe we can administer through circulation prior to freezing,
chemicals engineered for time release in the cells?

A time release of chemicals in each cell, can be used to replicate
what chemicals those cells produce that naturally survive
freezing, so that we can trigger the right release of chemicals
at the right time in each cell even when these are in the freezing
and thawing process and can't be reached by outside circulation.

What reactions take place in cells that naturally survive
freezing and cooling? 
How replicate these?

One approach might be to search for ways to 
lower the freezing point for body fluids,
ways to freeze body fluids without crystals forming,
and at the same time heigthen the temperature where body fluids
freeze without forming crystals.

Maybe we can lower the freezing point to below the point for
freezing without crystal formation so to avoid crystal formation
all together?

For starters what can we do to lower the freezing point for water?
what can we do to freeze water without forming crystals?
and if we find a way to do the latter
what can we do to increase the temperature where water
freeze without forming crystals?

Does airpressure or gravity have any effect 
on freezing point and crystal forming?
What chemicals are the best anti freeze?
what chemicals prevent crystal formation?

Or what can we do to remove enough water before freezing
so that whatever is left can form crystals without doing harm?

What capacity do cells and tissues have to survive crystal
formation?
And how can we lower the water content
and increase the capacity to survive crystals
so that an organ can survive the crystals that form?

How can we freeze the cells so that the water that
leave the cells during a gradual freezing are brought away
and do not form harmful crystals outside the cells?

Can we find a way to lower the freezing point for body fluids
and prevent fluid coagulation,
so that we can keep up circulation and get to remove most of
the water before the vessels freeze up on us?

Or can we find ways to lengthen the shelf lives of organs
without freezing these?
Can we create a portable life support system
a kind of artificial youth that we can attach the organ too
so to keep it healthy and functioning until we can implant it?

Or how can we suspend animation or at least slow down metablism
at higher temperatures?

How can we systematically find instances of
suspended animation or slowed metabolism in nature?

We know that some plants produce chemicals to withstand the cold
when they experience more darkness and a gradual cooling & drying.

What similar responses can we trigger or induce
in the human body by slowing its metabolism?
 
How can we replicate natures ways of hibernating?

What about feeding well for a while
and then stop adding more nutrients, but keep rinsing away the
waste from metabolism, and induce relaxation,
dryness, some cooling and gradual absence of oxygen
while keeping all disturbances and all other distress away?

What about fasting combined with continuous detoxification and
otherwise just induced rest, slowed breath
and maybe even drying and gradual cooling
or all this prior to freezing?

What about stopping one's food intake and then gradually reducing
one's water intake or otherwise inducing dehydration? 
It would definitively reduce the water content in the body,
and concentrate and change the body fluids and maybe even induce
the creation of certain chemicals or chemical concentrations that
lower the freezing point of body fluids?

The yogi tradition have a lot of routines
for reaching suspended animation at room temperature 
maybe we can improve freezing, or reduce frost damage
by inducing suspended animation by yocic means
or by otherwise replicating yogic suspension
before cooling and freezing?

Something could be said for applying the latest medical means
to induce in patients what yogis only accomplished by
life time training.

There are easier ways for cleansing the digestive system
and for slowing one's breath than those developed in yoga.
Maybe we could develop simple medical routines
for inducing suspended animation at room temperature
or at temperatures just above freezing?

Something can be said for low temperature medicine,
the body consumes less oxygen, and less blood is needed
during surgery.

What we should learn from yoga, is that we need to keep up
circulation and detoxification going into and out of the
suspended animation so that harmful concentrations of metabolic 
byproducts are not permitted to build up in any cell or tissue.

Putting organs on a life support system including nutritious blood,
liver-, gall- & kidney- dialysis, both while we cool the organs and
while we reheat them, might drastically increase their survival.

If we by various means lower the temperature where crystals form
and increase the temperature where all biological activity
has stopped, maybe we can reach and maintain suspended animation
at high enough temperatures to avoid crystal forming all together?

In our search for ways to make organs survive freezing and thawing
we could benefit from more research on what actually take place
during the freezing and thawing of such cells and organisms
that naturally survive freezing and thawing.

If we find a way to suspend animation in or lower metabolism in
organisms this can be applied to organs too, and vise versa.
Likewise, ability to make organs survive freezing and thawing
is a step towards achieving the same for whole human beings.

Long life,

    Trygve B. Bauge     


I am coordinating my life extending ventures, including my
political fights, from Oslo, Norway. Please publish where others
can get hold of me. To offer your assistance contact me at the
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Trygve Bauge C/O Active Life Extension, Universal Liberty, 
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Also reachable at the above addresses: Life Extension Systems,
Biosphere Technologies & Private Fortifications Unlimited; The
Rocky Mountain Life Extension Center & the Boulder Polar Bear Club.


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